It is a sulfonamide diuretic that is pharmacologically related to thiazide diuretics. The medicine inhibits sodium reabsorption in the cortical segment of the kidneys. It increases the excretion of sodium and chlorides in the urine and the excretion of potassium and magnesium, thus increasing diuresis. The antihypertensive effect of the active components appears at doses at which the diuretic effect is insignificant. Moreover, its antihypertensive effect persists even in patients with hypertension.
Lozol
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2.5mg × 180 Pills | $0.99 | $178.01 + Bonus - 11 Pills | $171.00 | Add to cart |
2.5mg × 270 Pills | $0.93 | $249.85 + Bonus - 11 Pills Free Trackable Delivery | $272.70 | Add to cart |
2.5mg × 360 Pills | $0.89 | $321.69 + Bonus - 11 Pills Free Trackable Delivery | $378.00 | Add to cart |
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The tablets are aimed at reducing the ability of smooth muscle vessels to contract and to stimulate the synthesis of prostaglandin PGE2 and prostacyclin PGI2 (vasodilator and platelet aggregation inhibitor).
Product Description
The pills increase the excretion of sodium in the urine, and to a lesser extent the release of magnesium and potassium. Thus the action of diuresis becomes faster. The effect of the drug persists even in people with hypertension. The medicine operates at the level of the vessels. It decreases the contractility of the muscles of blood vessels, stimulates indapamide in blood vessels, and reduces left ventricular hypertrophy.
According to studies that had different duration-short, medium and long, it has been determined that the pills do not affect the metabolism of lipids, triglycerides, low-density lipoprotein cholesterol and high-density lipoprotein; they do not influence the metabolism of carbohydrates, even in patients with hypertension and diabetes. If the recommended dose is exceeded, then the therapeutic effect of the components of the tablet will not be greater and the frequency of adverse reactions will increase. One should not increase the dose if the treatment is ineffective.
Safety Information
The tablets are not recommended and are contraindicated for people who have a high sensitivity to them or any other excipients. The pills are not recommended for people with severe renal insufficiency, with severe liver function disorders, with hypokalemia. It is not advised to combine medicine with lithium at a high level of its concentration in plasma may appear. They will be together with the symptoms of overdose with a salt-free diet. If you are appointed a diuretic, it is necessary to conduct a thorough study of the level of lithium in the blood.
If you take pills with the drugs mentioned above, there is a risk of gastric arrhythmia and gastric tachycardia or hypokalemia. Before taking this combination of tablets you need to check the level of potassium and correct it to a normal level if necessary. It is also necessary to control the level of plasma electrolytes. If there is hypokalemia, you need to take drugs that do not cause wave burst arrhythmia.
The best time for taking remedy is in the morning, 1 tablet (0.0015 g), without grinding, without chewing and washing with a ½ cup of water. The maximum daily dose - 1 tablet (0.0015 g).
Side Effects
A large number of negative effects (clinical or laboratory parameters are known to depend on the dose of the pill) can cause such adverse reactions as:
- Thrombocytopenia, hemolytic anemia, leukopenia, agranulocytosis;
- Dizziness (vertigo), fatigue, headache, paresthesia; fainting.
- Arrhythmia, hypotension; paroxysmal ventricular tachycardia;
- Vomiting; nausea, constipation, dry mouth; pancreatitis;
- Renal failure.
Patients with hypersensitivity who had a high predisposition to allergies and asthma, maculopapular rash; purpura; angioedema and/or urticaria, toxic epidermal necrolysis.
Cipro - the antimicrobic broad-spectrum agent derivative of fluroquinolone, suppresses bacterial DNA gyrase, breaks DNA synthesis, growth and division of bacteria; causes prominent morphological changes and fast death of a bacterial cell. It effects bactericidal at gram-negative organisms during a dormant period and deletion, on gram-positive microorganisms - only during deletion. During taking Cipro there is no parallel development of resistance to other antibiotics, which do not belong to group of inhibitors of a gyrase that does it highly effective in relation to bacteria which can be steady, for example to aminoglycosides, penicillin, cephalosporins, tetracyclines and many other antibiotics.
ED Trial Pack (2 Viagra + 2 Cialis + 2 Levitra) - a trial set consists of six tablets, for those who want to understand what medicine is better for him. Includes 6 tablets (by 2 pсs.): Viagra, Cialis and Levitra. It can be taken by people older than 18 years, in case of problems in private life related to fatigue, stress, sleep debt, slow-moving way of life and abuse of addictions.
Cialis Super Active is a generic drug, against erectile dysfunction, containing 20 mg of tadalafil. The tablets in this series have a gel inside. This form allows the active substance, Tadalafil, to immediately enter the blood, thus providing an immediate effect. The result from the Cialis Super Active tablets appears after 5 minutes! The action lasts for two days. The drug is safe and has virtually no contraindications.
Cialis Professional - effective tablets for improvement of erection. They begin to work in 15 minutes from the moment of taking and actions for 36 hours. They can cause not less than 10, but no more than 16 erections. The medicine increases duration of sexual intercourse. The tablets are successfully used for reduction of time for recovery of erection after ejaculation.
Dutas is a mix of two medicines: dutasteride and tamsulosin hydrochloride. The drugs have complementary mechanisms of action, due to which there is a rapid weakening of urination. It reduces the risk of retention of the urine. It is not anticipated that the pharmacodynamic reactions of a fixed dosage mix of dutasteride-tamsulosin differ from those obtained with the simultaneous use of dutasteride and tamsulosin as separate elements. Dutasteride inhibits the activity of both the 1st and 2nd type of isoenzymes. DHT is an androgen that is responsible for prostate and the increase of BPH. It inhibits the activity of adrenoreceptors.
Peripheral vasodilator with predominant effect on venous vessels. It is used for the prevention of angina in CHF, hypertension in the "small" circulation, "pulmonary" heart (treatment as a part of combination therapy), spasm of peripheral arteries (obliterating endarteritis, angiospastic retinitis)